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Data & Documentation

MOST has collected both clinical data from case report forms (questionnaires and examinations) and knee joint images from radiographs and MRI.

Study Time Points and Assessments

Operations Manuals

Clinical Datasets

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Outcomes Datasets

Biological Specimen Collection

Biospecimens were collected from enrolled MOST participants at baseline, 30 months, and 60 months. For more information, click on the link below.

Knee Radiograph and MR Imaging

  • MR Images Available
  • Axial, sagittal and coronal MRI images are available for each knee scanned

    Multicenter Osteoarthritis Study knee axial MR image
    (Click for sample image)


    Multicenter Osteoarthritis Study knee sagittal MR image
    (Click for sample image)


    Multicenter Osteoarthritis Study knee coronal MR image
    (Click for sample image)

    For details about the acquisition protocols, see the 1.0T MRI Operations Manual.

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Longitudinal Radiograph Assessments

    Semi-quantitative scoring of radiographs, including Kellgren and Lawrence grades, OARSI joint space narrowing, osteophyte grades, and features of patello-femoral OA

  • Baseline to 84-month Longitudinal Knee Radiograph Assessments (V01235XRAY)

  • Baseline to 60-month Longitudinal Knee Radiograph Assessments (V0123XRAY)
    • As of April 2016, the Baseline to 60-month Longitudinal Radiograph Assessments dataset (V0123XRAY) is no longer available. This data has been updated and is now available in the Longitudinal Baseline to 84 Longitudinal Knee Radiograph Assessments dataset (V01235XRAY).
  • Baseline to 15-month and 30-month Longitudinal Knee Radiograph Assessments (V012XRAY)
    • As of September 2013, the Baseline to 15-month and 30-month Longitudinal Radiograph Assessments dataset (V012XRAY) is no longer available.

Longitudinal MR Image Assessments

Imaging Resources
GE Healthcare (previously ONI Medical Systems, Inc.) Manufacturer of OrthOne 1.0T and 1.5T MRI scanners
Information Resource for MRI Safety, Bioeffects, and Patient Management
Developed by Frank G. Shellock, PhD, Physiologist

Imaging Literature
(Sorted by publication date, most recent at top)

Stefanik JJ, Guermazi A, Roemer FW, Peat G, Niu J, Segal NA, Lewis CE, Nevitt M, Felson DT.
Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study.
Osteoarthritis Cartilage. 2016 Feb 4. pii: S1063-4584(16)01000-1. doi: 10.1016/j.joca.2016.01. 981. Epub ahead of print. PMID: 26836287.

Guermazi A, Eckstein F, Hayashi D, Roemer FW, Wirth W, Yang T, Niu J, Sharma L, Nevitt MC, Lewis CE, Torner J, Felson DT.
Baseline radiographic osteoarthritis and semi-quantitatively assessed meniscal damage and extrusion and cartilage damage on MRI is related to quantitatively defined cartilage thickness loss in knee osteoarthritis: the Multicenter Osteoarthritis Study.
Osteoarthritis Cartilage. 2015 Dec;23(12):2191-8. doi: 10.1016/j.joca.2015.06.017. Epub 2015 Jul 8. PMID: 26162806.

Stefanik JJ, Gross KD, Guermazi A, Felson DT, Roemer FW, Niu J, Lynch JA, Segal NA, Lewis CE, Lewis CL.
The relation of step length to MRI detected structural damage in the patellofemoral joint: The Multicenter Osteoarthritis Study.
Arthritis Care Res (Hoboken). 2015 Sep 28. doi: 10.1002/acr.22738. Epub ahead of print. PMID: 26413842. PMCID: PMC4809780.

Sheehy L, Culham E, McLean L, Niu J, Lynch J, Segal NA, Singh JA, Nevitt M, Cooke TD.
Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis Study (MOST).
Osteoarthritis Cartilage. 2015 Sep;23(9):1491-8. doi: 10.1016/j.joca.2015.05.003. Epub 2015 May 21. PMID: 26003948. PMCID: PMC4831715.

Guermazi A, Hayashi D, Roemer F, Felson DT, Wang K, Lynch J, Amin S, Torner J, Lewis CE, Nevitt MC.
Severe radiographic knee osteoarthritis: Does Kellgren and Lawrence grade 4 represent end stage disease? The MOST study.
Osteoarthritis Cartilage. 2015 Sep;23(9):1499-505. doi: 10.1016/j.joca.2015.04.018. Epub 2015 Apr 28. PMID: 25929973. PMCID: PMC4558267.

Stefanik JJ, Gross KD, Guermazi A, Felson DT, Roemer FW, Zhang Y, Niu J, Segal NA, Lewis CE, Nevitt M, Neogi T.
The relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: The Multicenter and Framingham Osteoarthritis Studies.
Osteoarthritis Cartilage. 2015 Apr;23(4):565-70. doi: 10.1016/j.joca.2014.12.023. Epub 2015 Jan 7. PMID: 25575967. PMCID: PMC4368472.

Crema MD, Nevitt MC, Guermazi A, Felson DT, Wang K, Lynch JA, Marra MD, Torner J, Lewis CE, Roemer FW.
Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA - the MOST study.
Osteoarthritis Cartilage. 2014 Oct;22(10):1743-7. doi: 10.1016/j.joca.2014.07.008. PMDI: 25278083. PMCID: PMC4187213.

Stefanik J, Neogi T, Roemer F, Segal NA, Lewis CE, Nevitt MC, Guermazi A, Felson DT.
The diagnostic performance of anterior knee pain and pain with activities in identifying knees with structural damage in the patellofemoral joint: the Multicenter Osteoarthritis Study.
J Rheumatol. 2014 Aug;41(8):1695-702. doi: 10.3899/jrheum.131555. Epub 2014 Jun 15. PMID: 24931959. PMCID: PMC4182011.

Boissonneault A, Lynch JA, Wise BA, Segal NA, Gross KD, Murray DW, Nevitt MC, Pandit HG.
Association of hip and pelvic geometry with tibiofemoral osteoarthritis: Multicenter Osteoarthritis Study (MOST).
Osteoarthritis Cartilage. 2014 Aug;22(8):1129-35. doi: 10.1016/j.joca.2014.06.010. Epub 2014 Jun 24. PMID: 24971867. PMCID: PMC4195737.

Guermazi A, Hayashi D, Roemer FW, Zhu Y, Niu J, Crema MD, Javaid MK, Marra MD, Lynch JA, El-Khoury GY, Zhang Y, Nevitt MC, Felson DT.
Synovitis in knee osteoarthritis assessed by contrast-enhanced Magnetic Resonance Imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study.
J Rheumatol. 2014 Mar;41(3):501-8. doi: 10.3899/jrheum.130541. PMID: 24429179.

Guermazi A, Hayashi D, Jarraya M, Roemer FW, Zhang Y, Niu J, Crema MD, Englund M, Lynch JA, Nevitt MC, Torner JC, Lewis CE, Felson DT.
Medial posterior meniscal root tears are associated with development or worsening of medial tibiofemoral cartilage damage: the Multicenter Osteoarthritis Study.
Radiology. 2013 Sep;268(3):814-821. Epub 2013 May 21. PMID: 23696679. PMCID: PMC3750419.

Stefanik JJ, Zumwalt AC, Segal NA, Lynch JA, Powers CM.
Association between measures of patella height, morphologic features of the trochlea, and patellofemoral joint alignment: the MOST study.
Clin Orthop Relat Res. 2013 Aug;471(8):2641-8. doi: 10.1007/s11999-013-2942-6. Epub 2013 Apr 2. PMID: 22956600. PMCID: PMC3705075.

Roemer FW, Felson DT, Wang K, Crema MD, Neogi T, Zhang Y, Nevitt MC, Marra MD, Lewis CE, Torner J, Guermazi A; for MOST study investigators.
Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study.
Ann Rheum Dis. 2013 Jun;72(6):942-8. doi: 10.1136/annrheumdis-2012-201810. Epub 2012 Sep 6. PMID: 22956600. PMCID: PMC3871211.

Roemer FW, Felson DT, Yang T, Niu J, Crema MD, Englund M, Nevitt MC, Zhang Y, Lynch JA, El Khoury GY, Torner J, Lewis CE, Guermazi A.
The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI - the MOST Study.
Semin Arthritis Rheum. 2013 Jun;42(6):573-81. doi: 10.1016/j.semarthrit.2012.10.005. Epub 2012 Dec 25. PMID: 23270763. PMCID: PMC3640766.

Crema MD, Felson DT, Roemer FW, Niu J, Marra MD, Zhang Y, Lynch JA, El-Khoury GY, Lewis CE, Guermazi A.
Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. the MOST study.
Osteoarthritis Cartilage. 2013 Mar;21(3):413-8. doi: 10.1016/j.joca.2012.12.006. Epub 2012 Dec 28. PMID: 23277189. PMCID: PMC3578385.

Crema MD, Felson DT, Roemer FW, Wang K, Marra MD, Nevitt MC, Lynch JA, Torner J, Lewis CE, Guermazi A.
Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study.
Osteoarthritis Cartilage. 2013 Feb;21(2):306-13. doi: 10.1016/j.joca.2012.11.005. Epub 2012 Nov 23. PMID: 23178289. PMCID: PMC3556203.

Felson DT, Niu J, Gross KD, Englund M, Sharma L, Cooke TD, Guermazi A, Roemer FW, Segal N, Goggins JM, Lewis CE, Eaton C, Nevitt MC.
Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative.
Arthritis Rheum. 2013 Feb;65(2):355-62. doi: 10.1002/art.37726. PMID: 23203672. PMCID: PMC3558618.

Sharma L, Chmiel JS, Almagor O, Felson D, Guermazi A, Roemer F, Lewis CE, Segal N, Torner J, Cooke TD, Hietpas J, Lynch J, Nevitt M.
The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study.
Ann Rheum Dis. 2013 Feb;72(2):235-40. doi: 10.1136/annrheumdis-2011-201070. Epub 2012 May 1. PMID: 22874524. PMCID: PMC3845483.

Hayashi D, Englund M, Roemer FW, Niu J, Sharma L, Felson DT, Crema MD, Marra MD, Segal NA, Lewis CE, Nevitt MC, Guermazi A.
Knee malalignment is associated with an increased risk for incident and enlarging bone marrow lesions in the more loaded compartments: the MOST study.
Osteoarthritis Cartilage. 2012 Nov;20(11):1227-33. doi: 10.1016/j.joca.2012.07.020. Epub 2012 Aug 5. PMID: 22874524. PMCID: PMC3448813.

Roemer FW, Nevitt MC, Felson DT, Niu J, Lynch JA, Crema MD, Lewis CE, Torner J, Guermazi A.
Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint - the MOST study.
Osteoarthritis Cartilage. 2012 Nov;20(11):1391-8. doi: 10.1016/j.joca.2012.07.012. Epub 2012 Jul 27. PMID: 22846715. PMCID: PMC3863692.

Gross KD, Niu J, Stefanik JJ, Guermazi A, Roemer FW, Sharma L, Nevitt MC, Segal NA, Lewis CE, Felson DT.
Breaking the law of valgus: the surprising and unexplained prevalence of medial patellofemoral cartilage damage.
Ann Rheum Dis. 2012 Nov;71(11):1827-32. doi: 10.1136/annrheumdis-2011-200606. Epub 2012 Apr 25. PMID: 22534825. PMCID: PMC4011177.

Anderson DD, Segal NA, Kern AM, Nevitt MC, Torner JC, Lynch JA.
Reliability of semi-automated computational methods for estimating tibiofemoral contact stress in the Multicenter Osteoarthritis Study.
Comput Math Methods Med. 2012;2012:767469. doi: 10.1155/2012/767469. Epub 2012 Oct 14. PMID: 23097679. PMCID: PMC3477762.

Segal NA, Kern A, Anderson DD, Niu J, Lynch J, Guermazi A, Torner JC, Brown TD, Nevitt M; for the Multicenter Knee Osteoarthritis Study Group.
Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months.
Osteoarthritis Cartilage. 2012 Oct;20(10):1120-6. Epub 2012 Jun 12. PMID: 22698440. PMCID: PMC3427397.

Crema MD, Roemer FW, Felson DT, Englund M, Wang K, Jarraya M, Nevitt MC, Marra MD, Torner JC, Lewis CE, Guermazi A.
Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: the Multicenter Osteoarthritis (MOST) Study.
Radiology. 2012 Aug;264(2):494-503. Epub 2012 May 31. PMID: 22653191. PMCID: PMC3401352.

Wise BL, Niu J, Yang M, Lane NE, Harvey W, Felson DT, Hietpas J, Nevitt M, Sharma L, Torner J, Lewis CE, Zhang Y; Multicenter Osteoarthritis (MOST) Group.
Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans.
Arthritis Care Res (Hoboken). 2012 Jun;64(6):847-52. doi: 10.1002/acr.21606. Epub 2012 Jan 11. PMID: 22238208. PMCID: PMC3340516.

Stefanik JJ, Roemer FW, Zumwalt AC, Zhu Y, Gross KD, Lynch JA, Frey-Law LA, Lewis CE, Guermazi A, Powers CM, Felson DT.
Association between measures of trochlear morphology and structural features of patellafemoral joint osteoarthritis on MRI: the MOST study.
J Orthop Res. 2012 Jan;30(1):1-8. doi: 10.1002/jor.21486. Epub 2011 Jun 24. PMID: 21710542. PMCID: PMC3217080.

Stefanik JJ, Guermazi A, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Segal NA, Lewis CE, Roemer FW, Powers CM, Felson DT.
Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis.
Arthritis Care Res (Hoboken). 2011 Oct;63(10):1391-7. Epub 2011 Sep 27. PMID: 21702087. PMCID: PMC3183313.

Englund M, Felson DT, Guermazi A, Roemer FW, Wang K, Crema MD, Lynch JA, Sharma L, Segal NA, Lewis CE, Nevitt MC.
Risk factors for medial meniscal pathology on knee MRI in older U.S. adults: a multicentre prospective cohort study.
Ann Rheum Dis. 2011 Oct;70(10):1733-9. Epub 2011 Jun 6. PMID: 21646417. PMCID: PMC21646417.

Roemer FW, Guermazi A, Felson DT, Niu J, Nevitt MC, Crema MD, Lynch JA, Lewis CE, Torner JC, Zhang Y.
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study.
Ann Rheum Dis. 2011 Oct;70(10):1804-9. Epub 2011 Jul 25. PMID: 21791448. PMCID: PMC3496084.

Zhang Y, Nevitt M, Niu J, Lewis C, Torner J, Guermazi A, Roemer F, McCulloch C, Felson D.
Fluctuation of knee pain and changes in bone marrow lesions, effusions and synovitis on MRI: The MOST study.
Arthritis Rheum. 2011 Mar;63(3):691-9. doi: 10.1002/art.30148. PMID: 21360498. PMCID: PMC3056156.

Roemer FW, Lynch JA, Niu J, Zhang Y, Crema M, Tolstykh I, El-Khoury GY, Felson DT, Lewis CE, Nevitt MC, Guermazi A.
A comparison of dedicated 1.0 T extremity MRI vs. large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study.
Osteoarthritis Cartilage. 2010 Feb;18(2):168-74. doi: 10.1016/j.joca.2009.08.017. Epub 2009 Sep 9. PMID: 19766580. PMCID: PMC2818134.

Roemer FW, Guermazi A.
MR imaging-based semiquantitative assessment in osteoarthritis.
Radiol Clin North Am. 2009 Jul;47(4):633-54. PMID: 19631073.

Roemer FW, Guermazi A, Zhang Y, Yang M, Hunter DJ, Crema MD, Bohndorf K.
Hoffa's Fat Pad: Evaluation on Unenhanced MR Images as a Measure of Patellofemoral Synovitis in Osteoarthritis.
AJR Am J Roentgenol. 2009 Jun;192(6):1696-700. PMID: 19457837.

Englund M, Guermazi A, Roemer FW, Aliabadi P, Yang M, Lewis CE, Torner J, Nevitt MC, Sack B, Felson DT.
Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study.
Arthritis Rheum. 2009 Mar;60(3):831-9. PMID: 19248082. PMCID: PMC2758243.

Guermazi A, Hunter DJ, Roemer FW.
Plain radiography and magnetic resonance imaging diagnostics in osteoarthritis: validated staging and scoring.
J Bone Joint Surg Am. 2009 Feb;91 Suppl 1:54-62. PMID: 19182026.

Felson DT, Nevitt MC, Yang M, Clancy M, Niu J, Torner JC, Lewis CE, Aliabadi P, Sack B, McCulloch C, Zhang Y.
A new approach yields high rates of radiographic progression in knee osteoarthritis.
J Rheumatol. 2008 Oct;35(10):2047-54. Epub 2008 Sep 15. PMID: 18793000. PMCID: PMC2758234.

Nevitt MC, Peterfy C, Guermazi A, Felson DT, Duryea J, Woodworth T, Chen H, Kwoh K, Harris TB.
Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss.
Arthritis Rheum. 2007 May;56(5):1512-20. PMID: 17469126.

Bruyere O, Genant H, Kothari M, Zaim S, White D, Peterfy C, Burlet N, Richy F, Ethgen D, Montague T, Dabrowski C, Reginster JY.
Longitudinal study of magnetic resonance imaging and standard X-rays to assess disease progression in osteoarthritis.
Osteoarthritis Cartilage. 2007 Jan;15(1):98-103. Epub 2006 Aug 4. PMID: 16890461.

Altman RD, Gold GE.
Atlas of individual radiographic features in osteoarthritis, revised.
Osteoarthritis Cartilage. 2007;15 Suppl A:A1-56. PMID: 17320422.

Peterfy C, Kothari M.
Imaging osteoarthritis: magnetic resonance imaging versus x-ray.
Curr Rheumatol Rep. 2006 Feb;8(1):16-21. PMID: 16515760.

Roemer FW, Guermazi A, Lynch JA, Peterfy CG, Nevitt MC, Webb N, Li J, Mohr A, Genant HK, Felson DT.
Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol.
Eur Radiol. 2005 May;15(5):978-87. Epub 2005 Jan 5. PMID: 15633060.

Kothari M, Guermazi A, von Ingersleben G, Miaux Y, Sieffert M, Block JE, Stevens R, Peterfy CG.
Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis.
Eur Radiol. 2004 Sep;14(9):1568-73. Epub 2004 May 19. PMID: 15150666.

Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK.
Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis.
Osteoarthritis Cartilage. 2004 Mar;12(3):177-90. PMID: 14972335.

Felson DT, McAlindon TE, Anderson JJ, Naimark A, Weissman BW, Aliabadi P, Evans S, Levy D, LaValley MP.
Defining radiographic osteoarthritis for the whole knee.
Osteoarthritis Cartilage. 1997 Jul;5(4):241-50. PMID: 9404469.

Kellgren JH, Lawrence JS.
Radiological assessment of osteo-arthrosis.
Ann Rheum Dis. 1957;16:494502. PMID: 13498604. PMCID: PMC1006995.