Multicenter Osteoarthritis Study (MOST) Public Data Sharing

IMPORTANT NOTICE: MOST Online/UCSF is no longer involved in public sharing of MOST Public Use Limited Datasets and/or Images, due to the end of funding and closeout of MOST.

In fall 2021, MOST public use data sets will be available through the NIA AgingResearchBiobank, a web-based platform for sharing biospecimens and data with investigators in the research community. If you are interested in requesting MOST public use data and/or biospecimens, please visit the NIA AgingResearchBiobank website in fall 2021 for more information.  


The Multicenter Osteoarthritis Study (MOST) is a prospective observational study of risk factors for the development and progression of knee osteoarthritis and knee pain.

MOST is a nationwide research study, sponsored by the National Institutes of Health / National Institute on Aging (part of the Department of Health & Human Services), that will help us better understand how to prevent and treat knee osteoarthritis, one of the most common causes of disability in adults. MOST is a collaborative effort developed by investigators at four core sites and funded by NIH/NIA grants: U01 AG18820 (David Felson, Boston University); U01 AG18947 (Cora E. Lewis, University of Alabama at Birmingham); U01 AG18832 (James Torner, University of Iowa); U01 AG19069 (Michael Nevitt, University of California, San Francisco).

Summary of Data and Images

Clinical Data

  • 84-month Telephone Interview and Clinic Visit (N=2638 participants)
  • 72-month Telephone Interview (N=2715 participants)
  • 60-month Telephone Interview and Clinic Visit (N=2768 participants)
  • 30-month Telephone Interview and Clinic Visit (N=2969 participants)
  • 15-month Telephone Interview and Clinic Visit (N=3007 participants)
  • Baseline Telephone Screen and Clinic Visit (N=3026 participants)

Radiograph Images

  • 84-month PA and Lateral View Radiographs (N=3921 knees / 1961 participants)
  • 60-month Full-limb View Radiographs (N=2100 participants)
  • 60-month PA and Lateral View Radiographs (N=4228 knees / 2114 participants)
  • 30-month PA and Lateral View Radiographs (N=5302 knees / 2651 participants)
  • 15-month PA and Lateral View Radiographs (N=586 knees / 293 participants)
  • Baseline Full-limb View Radiographs (N=3011 participants)
  • Baseline PA and Lateral View Radiographs (N=6030 knees / 3015 participants)

Radiograph Assessments

  • Longitudinal Baseline to 84-month PA and Lateral Knee Radiograph Assessments - includes Baseline and 60-month Full-limb (Hip-Knee-Ankle) Mechanical Alignment Assessments (N=3026 participants)

MR Images

  • 84-month MR Images (N=2753 knees/ 1512 participants)
  • 60-month MR Images (N=3031 knees / 1648 participants)
  • 30-month MR Images (N=4244 knees / 2224 participants)
  • 15-month MR Images (N=820 knees / 575 participants)
  • Baseline MR Images (N=5029 knees / 2597 participants)

MRI Assessments (WORMS)

  • Baseline to 60-month to 84-month (N=1182 knees)
  • Baseline to 30-month Incident Radiographic OA Cases and Controls (N= 444 knees)
  • Baseline to 30-month Subset of Knees with Baseline OA (N= 597 knees)
  • Baseline to 15-month Incident Knee Symptoms Cases and Controls (N= 415 knees)

Outcomes Data

  • Outcomes: Baseline to 84-month Knee and Hip Replacements, Radiographic OA and Death Outcomes